Metoclopramide Poisoning

Metoclopramide only containing medicinal products International Non-proprietary Name: metoclopramide

Metoclopramide-induced cardiac arrest

The authors report a case of cardiac arrest in a patient receiving intravenous (IV) metoclopramide and review the pertinent literature. A 62-year-old morbidly obese female admitted for a gastric sleeve procedure, developed cardiac arrest within one minute of receiving metoclopramide 10 mg via slow intravenous (IV) injection. Bradycardia at 4 beats/min immediately appeared, progressing rapidly t...

Metoclopramide-induced Serotonin Syndrome

A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide. Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and muscle rigidity were consistent with a diagnosis of serotonin syndrome (SS) according to the Hunter ...

Metoclopramide and gastric emptying.

Sir,—In view of increasing interest in the effect of metoclopramide on the gastric emptying rate, may I briefly describe the results of a short trial carried out in the clinical situation as an addition to the information so far available on a drug action which could be of importance to anaesthesia. Under double-blind conditions, 39 patients appearing consecutively for emergency surgery were gi...

Metoclopramide in gastrooesophageal reflux.

In 30 patients with gastrooesophageal reflux, intravenous metoclopramide (Maxolon) has been shown to increase the gastrooesophageal sphincter pressure. The rise is dose-related until a maximum pressure, proportional to the resting sphincter tone, is reached. The effect is reversed by atropine. Peristaltic waves are increased in pressure by metoclopramide.In 18 patients with gastrooesophageal re...